SDTL BONE
Regenerates bone, breaking the concept that bone cannot regrow
Has important research and application value in reducing osteoporotic fractures and greatly reduce post-fracture mortality
Topical application of SDTL-Bone for just 20 days can inhibit bone calcium loss and calcium ion transfer to the blood, and can significantly restore bone strength and hardness back to normal level
ANIMAL STUDIES
After 90 days, ovariectomized rats showed osteoporosis symptoms
For next 20 days,
SDTL group rats were percutaneously given SDTL-Bone Model group and control group were percutaneously given vegetable oil
SDTL-Bone treatment percutaneously for 20 days significantly improved bone torsion, torque, shear stress (P<0.05) and shear modulus when compared to model group and restored these bone mechanics indicators to similar levels to that of the control group
Indicating significant therapeutic effect on osteoporosis by restoring bone strength and hardness to normal level
ALP is an important protein for bone metabolism and an important marker for osteoporosis
After SDTL-Bone treatment, SDTL group ALP returned to the level of the control group, the level was significantly (P <0.01) different compared to model group
Estradiol can act on osteoblast and increase bone mass. Declining estradiol levels is one of the main reasons for osteoporosis
After SDTL-Bone treatment, SDTL group estradiol returned to the level of the control group, the level was significantly (P <0.05) different compared to model group
Indicating SDTL-Bone increase osteoblast activity by resuming estradiol level
After SDTL-Bone treatment, SDTL group blood and urine calcium returned to close to the level of the control group, the levels were significantly (P <0.05) different compared to model group
Indicating that SDTL-Bone significantly inhibit osteoclasts activity and inhibit bone calcium loss and transfer to blood and urine
Osteoblasts decrease and osteoclasts increase lead to bone calcium loss, which is the main cause of osteoporosis and joint degeneration
Results suggest SDTL-Bone can inhibit osteoclast activity, increase osteoblast activity, enhance the utilization of calcium by osteoblasts, inhibit the transfer of bone calcium to the blood, and restore bone strength and hardness to normal level for alleviating osteoporosis